Ankylosing Spondylitis

Autoimmune Spinal Arthritis

Understanding Ankylosing Spondylitis: Symptoms, Diagnosis & Advanced Care

Ankylosing Spondylitis (AS) is a chronic autoimmune inflammatory disorder that primarily affects the spine and sacroiliac joints, causing pain, stiffness, and potential fusion of the vertebrae. Unlike mechanical back pain, AS occurs when the immune system mistakenly attacks the entheses — the sites where ligaments and tendons attach to bone. Early diagnosis and targeted treatment are crucial to managing symptoms, preventing spinal fusion, and improving quality of life. At IRIS Centre for Rheumatology, we offer world-class, patient-centric care for AS using the latest advances in rheumatology.

Ankylosing Spondylitis typically begins in early adulthood, most commonly between the ages of 20 and 40. Men are affected more frequently than women. The condition may also cause systemic inflammation affecting other organs such as the eyes (uveitis), skin, lungs, heart, and blood vessels. At IRIS, our multidisciplinary team ensures comprehensive management from early diagnosis to long-term remission strategies.

With our state-of-the-art immunodiagnostic laboratory, musculoskeletal ultrasound, and personalized treatment plans — including DMARDs, biologics, and physiotherapy — we aim to halt disease progression, relieve symptoms, and restore mobility. Healing begins with expert care and compassion.

Common Symptoms of Ankylosing Spondylitis

AS symptoms can vary in severity and may come and go. Early recognition leads to better outcomes.

• Chronic lower back and buttock pain
• Morning stiffness lasting more than 30 minutes
• Pain improves with exercise, worsens with rest
• Night pain that awakens from sleep
• Reduced spinal flexibility over time
• Inflammation in eyes (uveitis), heels, or chest wall